Enteric alpha defensins in norm and pathology
نویسندگان
چکیده
منابع مشابه
Guardians of the Gut: Enteric Defensins
Enteric defensins likely play a key role in the management of the human microbiome throughout development. The functional and mechanistic diversity of defensins is much greater than was initially thought. Defensin expression and overall Paneth cell physiology likely plays a key role in the development of colitis and other inflammatory or dysbiotic diseases of the gut. As our understanding of en...
متن کاملEnteric defensins: antibiotic peptide components of intestinal host defense
Five intestinal defensins, termed cryptdins 1-5, have been purified from mouse small bowel, sequenced, and localized to the epithelium by immunohistochemistry. Although identified as members of the defensin peptide family by peptide sequencing, enteric defensins are novel in that four cryptdins have amino termini which are three to six residues longer than those of leukocyte-derived defensins. ...
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α-defensins are abundant antimicrobial peptides with broad, potent antibacterial, antifungal, and antiviral activities in vitro. Although their contribution to host defense against bacteria in vivo has been demonstrated, comparable studies of their antiviral activity in vivo are lacking. Using a mouse model deficient in activated α-defensins in the small intestine, we show that Paneth cell α-de...
متن کاملReduced Paneth cell alpha-defensins in ileal Crohn's disease.
The pathogenesis of Crohn's disease (CD), an idiopathic inflammatory bowel disease, is attributed, in part, to intestinal bacteria that may initiate and perpetuate mucosal inflammation in genetically susceptible individuals. Paneth cells (PC) are the major source of antimicrobial peptides in the small intestine, including human alpha-defensins HD5 and HD6. We tested the hypothesis that reduced ...
متن کاملAlpha Defensins Genes and Vulvovaginal Candidiasis: A Study of Cases
Objective: To evaluate the alpha-defensin (α-DF) genes polymorphism in women with vulvovaginal candidiasis and recurrence. Methods: This observational study included clinical vaginal secretion samples collected over four years from 88 women, ranging in age from 18 to 65 years, from medical centers of São Paulo and Mogi das Cruzes, Brazil. Thirty-six of these women were asymptomatic (control gro...
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ژورنال
عنوان ژورنال: Annals of Clinical Microbiology and Antimicrobials
سال: 2012
ISSN: 1476-0711
DOI: 10.1186/1476-0711-11-1